Product Datasheet
|
Catalog Number |
ADT1185 |
|
Product Name |
Dupilumab Research Biosimilar |
|
Product Description |
Type 2 inflammatory processes in various allergic and atopic conditions, such as asthma and atopic diseases, involve the type 2 helper T-cell immunity. Upregulation of this Type 2/Th2 pathway is commonly observed in other inflammatory conditions and the activation of Th2 cells is linked to the production of Th2-associated cytokines, such as interleukin 4, IL-5, IL-9, and IL-13. IL-4 and IL-13 play a central role in inducing inflammatory conditions such as allergic rhinitis, asthma, and atopic dermatitis, by regulating Type 2 inflammation and immune function. These inflammatory cytokines work by modulating gene expression downstream of receptor signalling, regulating Th2 cell differentiation, and activating inflammatory cells such as mast cells and macrophages. |
|
CAS Number |
1190264-60-8 |
|
Chemical Formula |
C6512H10066N1730O2052S46 |
|
Clonity |
Monoclonal |
|
Target |
IL4R/CD124[Homo sapiens] |
|
Alias |
CD124, REGN668, SAR231893, Dupilumab Research Biosimilar |
|
Host |
CHO Cells |
|
Isotype |
IgG4 Kappa |
|
Size |
1mg,5mg |
|
Metabolism |
Being a monoclonal antibody, dupilumab is not expected to undergo significant hepatic metabolism. While the metabolism of dupilumab has not been characterized, it is speculated that dupilumab undergoes nonspecific degradation into smaller peptides and amino acids, as often observed with endogenous IgG. |
|
Buffer |
Supplied in PBS, PH7.5 |
|
Concentration |
Batch dependent, please contact our customer service to get the COAs of current batch |
|
Purity |
>95% as determined by SDS-PAGE |
|
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
|
Shipping Condition |
This product is shipped in blue ice. |
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