Product Datasheet
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Catalog Number |
ADT1642 |
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Product Name |
Teprotumumab Research Biosimilar |
|
Product Description |
Teprotumumab, sold under the brand name Tepezza, is a medication used to treat adults with thyroid eye disease, a rare condition where the muscles and fatty tissues behind the eye become inflamed, causing the eyes to bulge outwards. |
|
CAS Number |
1036734-93-6 |
|
Clonity |
Monoclonal |
|
Target |
IGF1R/CD221[Homo sapiens] |
|
Alias |
RO4858696-000, Teprotumumab Research Biosimilar |
|
Host |
CHO Cells |
|
Isotype |
IgG1 |
|
Size |
100ug,1mg,5mg |
|
Molecular Weight |
148.00 KDa |
|
Mechanism of Action |
Graves’ Disease is an autoimmune syndrome involving the thyroid, orbital connective tissues, and some regions of the skin. One manifestation of Graves’ Disease is thyroid-associated ophthalmopathy, or thyroid eye disease, which is characterized by orbital inflammation, tissue remodeling, and fibrosis. As the disease progresses, patients may develop proptosis, strabismus, corneal ulceration, and optic neuropathy. It has been demonstrated that insulin-like growth factor-1 receptors (IGF-1R) are overexpressed by orbital fibroblasts in patients with thyroid eye disease, in addition to being overexpressed on T-cells and B-cells in these patients5 It was found that Graves’ Disease IgG molecules could mimic the principal ligand of IGF-1R, insulin-like growth factor-1 (IGF-1), and their binding of IGF-1R induces the expression of chemokines that play roles in tissue remodeling and inflammation. For these reasons, IGF-1R was sought after as a potential therapeutic target for the treatment of thyroid eye disease. |
|
Metabolism |
The metabolism of teprotumumab has not been fully characterized. As a protein, its metabolism is expected to involve proteolysis to smaller proteins and peptides. |
|
Buffer |
Supplied in PBS, PH7.5 |
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Concentration |
Batch dependent, please contact our customer service to get the COAs of current batch |
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Purity |
>95% as determined by SDS-PAGE |
|
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
|
Shipping Condition |
This product is shipped in blue ice. |
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