Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a deadly epidemic that spreads rapidly and threatens global public health security.
According to the latest official data from governments and health ministries around the world, as of February 27, 2023, there have been 674,933,311 confirmed cases worldwide, including 6,870,013 deaths, and there have been more than 100,000 new cases every day for the past 2 years Cases, the COVID-19 is still threatening the safety and health of people all over the world, and the research on the pathogen SARS-CoV-2 has become a research hotspot in recent years and a difficult problem to be solved urgently.
Like other coronaviruses, SARS-CoV-2 is an enveloped virus, surrounded by a lipid bilayer into a spherical particle, which contains a positive-sense straned RNA encapsulated by a helically symmetrical nucleocapsid (N) protein. In addition, there are three transmembrane structural proteins including the envelope (E), membrane (M) and spike (S) protein, which are located at the 3' end of the SARS-CoV-2 genome (~30 Kb) together with the N protein. The SARS-CoV-2 genome additionally contains two relatively large open reading frames, ORF1a and ORF1b, which code for the synthesis of 16 nonstructural proteins (Nsp1 to 16).
The proteins encoded by SARS-CoV-2 can be used as important targets in the development of vaccines and diagnostic drugs. In the entire life cycle of SARS-CoV-2 from infecting cells to virus replication and massive release, firstly, a large number of glycosylated homotrimers covering the surface of SARS-CoV-2—the S protein specifically bind to angiotensin-converting enzyme 2 (ACE2) on the surface of host cells. The S protein is composed of two subunits, S1 and S2, among which the receptor binding domain (RBD) of the S1 subunit plays the role of binding ACE2. Subsequent TM protease serine 2 (TMPRSS2), also on the host cell membrane, hydrolyzes the S2 domain, resulting in fusion of the virus with the cell membrane and thus entry into the cell. In addition, SARS-CoV-2 has also been shown to directly enter cells through endocytosis.
After the virus enters the host cell, RNA is replicated and translated in large quantities, structural proteins are processed, and the most abundant M protein promotes the formation of the virus envelope. The N protein is involved in its assembly and repackaging to form virus particles. The E protein with the smallest molecular weight is involved in virus assembly and budding. Eventually the virus is released on the cell surface by exocytosis.
Alpha Lifetech Inc. mainly recommends SARS-CoV-2 self-encoded protein products to researchers and scientists around the world. In addition, Alpha Lifetech Inc. also focuses on proteins related to the virus entry mechanism, such as ACE2 protein and TMPRSS2 protein. Finally, we can also provide a variety of virus receptor proteins, immunoglobulins, innate immune antibodies, immune response antibodies, antibodies that inhibit the life process of viruses, etc.
Welcome to communicate with us about the products you are interested in. If there is no product you are interested in in the product list, we can also provide corresponding recombinant protein expression and antibody custom development services.
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