Biosimilar antibodies are developed with recombinant antibody expression technology using the same sequence as the therapeutic antibody and ensure specific binding to the same targeted molecule. The high quality biosimilar antibody products are usually produced in well-characterized cell lines with a long history of producing therapeutics. They can be used in extensive analytical studies, incluing the study of structure and function of biological product, determination of toxicity, and pharmacological studies involving the assessment of pharmacokinetic and pharmacodynamic profile.
The targets of biosimilar antibodies mainly focus on EGFR, TNF-α, VEGF, etc. EGFR can bind to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. TNF-α is a multifunctional cytokine secreted primarily by macrophages, natural killer (NK) cells, and lymphocytes. Vascular endothelial growth factor (VEGF) represents a growth factor with important pro-angiogenic activity, having a mitogenic and an anti-apoptotic effect on endothelial cells, increasing the vascular permeability, promoting cell migration, etc.
Figure 1. Mechanisms of action of EGFR inhibitors (Normanno et al., 2012)
Alpha Lifetech Inc. offers over 700 biosimilar antibody products against various targets. Our product list covers Adalimumab Biosimilar, Bevacizumab Biosimilar, Dupilumab Biosimilar, Eptinezumab Biosimilar, Rituximab Biosimilar, Teprotumumab Biosimilar, etc. Based on our professional antibody R&D team and rich experience in antibody expression production, we are confident in the quality of our biosimilar antibody products and strive to accelerate your research. Our biosimilar antibodies are available in a variety of sizes from ug to g level according to customers' demand. If there is no stock, it can be quickly expressed within 2-3 weeks.
Alpha Lifetech Inc. is a premier supplier of antibodies, proteins, ELISA kits, primary cells, cancer cell lines and related biological reagents, with extensive experience in protein expression, antibody development, library construction, cell line construction, and other services. As a professional antibody manufacturer and supplier, the biosimilar antibodies are produced based on our mature antibody expression platform. The antibodies undergo comprehensive validation testing to ensure high quality, high consistency and specific binding to the molecule targeted approved for research use.
Please check our list to choose the biosimilar antibody you need. For more information, please contact us and our technical support team will get back to you as soon as possible.
.jpg){kind=logo}
