Cell lines are in vitro model systems that are used extensively in various areas of biological research. Their utility is mainly related to their ability to supply an undefined source of biological material for experimental purposes. Under the right conditions and through appropriate controls, certified cancer cell lines retain most of the genetic properties of the original cancer. Cell line-based research had a major impact on the development of cancer treatment allowing an innumerable amount of effective drugs to be introduced into practice. Cell line authentication is important for credibility concern and scientific reproducibility. Experimental results commonly will be validated in more than one cell line to avoid specific cell line effect not generalizable to the disease on the whole.
Cancer cell lines are derived from the cancerous growth of a body in a human or animal subject. These cell lines have undergone laboratory modifications that make them immortalized—they have the ability to proliferate indefinitely in an in vitro environment. This is why cancer cell lines have become valuable tools for cancer research.
Biological Characteristics of Cancer Cells
Cancer cells differ significantly from normal cells in vivo and in vitro in terms of morphology, growth value, genetic characteristics, etc. The characteristics of cultured
tumour cells include: invasivenes, immortality and no contact inhibition.
Benefits and Applications of Cancer Cell Lines
Cancer cell lines continue to provide many important advantages to research, and there is little doubt that they will be a mainstay of the laboratory for many years to come. The main benefits from research on cancer cell lines include:
Wide variety: With literally thousands of human and animal cancer cell lines available, representing a wide range of biological origins, researchers have many options they can choose from.
Easy to use: Researchers can manipulate cancer cell lines in a variety of ways, such as using demethylation agents (to inhibit methylation) and cytostatic agents (to inhibit cell growth).
Tumour similarity: When well maintained, cancer cell lines retain most, if not all, of the genetic and epigenetic information associated with the initial tumour in vivo.
About Alpha Lifetech Inc.
Alpha Lifetech Inc. offers various diseased and normal cells from various tissue type found in the human and animal body. To accelerate the cancer biological research, Alpha Lifetech Inc. can provide over 500 types of cancer cell lines covering Hela, HepG2, 293T for researchers focused on specific cancer diseases (e.g., primary renal cell adenocarcinoma, thyroid carcinoma, lung carcinoma, epidermoid carcinoma, and prostate cancer). You can check our product list to choose the cancer cell lines you want. If you still have any related questions, please no hesitate to contact us. Our technical support team will get back to you as soon as possible.