Active magnetic particles (AMPs) are a type of nanoparticle that can be manipulated using an external magnetic field. These particles have shown great promise in various biomedical applications, including drug delivery, hyperthermia, and cancer therapy.
Active magnetic particles are a type of nanoparticle that contains a magnetic core and a coating that can be functionalized with specific ligands. The magnetic core is typically composed of iron oxide or other magnetic materials, while the coating is made of materials that are biocompatible and can be functionalized with ligands that target specific cells or tissues in the body.
An important features of AMPs is that it can be controlled remotely by using an external magnetic field. This makes it possible to accurately target specific cells or tissues in vivo, thereby improving the efficacy of drug delivery and reduce off-target effects. In addition, AMPs can be used for hyperthermia, a treatment that uses heat to destroy cancer cells. By applying an external magnetic field, AMPs can be heated up and used to selectively target cancer cells, while leaving healthy cells unharmed.
Biomedical Applications of Active Magnetic Particles
Active magnetic particles are a revolutionary technology, which shows great promise in various biomedical applications. By allowing for precise targeting of specific cells or tissues in the body, AMPs can improve the efficacy of drug delivery and reduce off-target effects. In addition, AMPs can be used for hyperthermia, magnetic separation, drug delivery, diagnostics and sensors.
--Drug delivery: Magnetic nanoparticles have been developed and applied for localized drug delivery to tumors. By functionalizing the coating of AMPs with specific ligands, they can be targeted to specific cells or tissues in the body. The magnetic nanoparticles first act as carriers of the drug, which is attached to its outer surface or dissolves in the coating. Once the drug coated particles have been introduced into the bloodstream of the patient, a magnetic field gradient is created by a strong permanent magnet to retain the particles in the targeted region. This makes the drug delivery more accurate and effective, while reducing off-target effects and toxicity.
Fig.1 drug delivery
--Hyperthermia: Hyperthermia is a treatment that uses heat to destroy cancer cells. Various types of superparamagnetic nanoparticles with different coatings and targeting agents are used for specific tumor sites. By applying an external magnetic field to AMPs, they can be heated up and used to selectively target cancer cells, while leaving healthy cells unharmed. The use of AMPs in hyperthermia therapy could improve the therapeutic effect and reduce side effects.
In addition, other applications of active magnetic nanoparticles in biomedicine include magnetic separation, diagnostics, and sensors.
Fig.2 Thermal therapy of active magnetic nanoparticles
Production of Active Magnetic Particles
The production of AMPs involves several steps, including synthesis, functionalization, and characterization.
1.synthesis techniques: co-precipitation, sol-gel, and hydrothermal. Co-precipitation involves the precipitation of iron salts in the presence of a base and a surfactant. Sol-gel involves the hydrolysis and condensation of metal alkoxides to form a gel, and then annealed to form nanoparticles. Hydrothermal methods involve the reaction of metal salts with a reducing agent in the presence of a surfactant in a high-temperature and high-pressure environment.
2.Functionalization techniques: the functionalization of AMPs involves the coating of the particles with a material that can be functionalized with specific ligands. Common coating materials include dextran, PEG, and silica. The coating material is typically functionalized with specific ligands, such as antibodies or peptides, that target specific cells or tissues in the body.
3.Characterization: characterization can determine size, shape, and magnetic properties. There are several techniques used in the characterization of AMPs, including transmission electron microscopy (TEM), dynamic light scattering (DLS), and vibrating sample magnetometry (VSM).
Product Description
Magnetic nanoparticles have a series of unique and superior physical and chemical properties, such as magnetic orientation, biocompatibility, small size effect, surface effect, etc., which can simplify the complicated traditional experimental methods and shorten the experimental time, it is a new and efficient reagent.
Alpha Lifetech Inc. provides a range of active magnetic particles in a variety of surface materials for research and commercial applications. We provides magnetic particles functionalized with various terminal active groups for further conjugation of affinity ligands. The conjugation between particles and ligands can be established by direct conjugation, click chemistry, or linker chemistry.
Specifications
1.Functional group: azide, DOTA, tosyl, PEG, Thiol, etc.
2.Available in particle size of 15 nm to 150 μm
3.Type of Magnetization: superparamagnetic
Quality advantage
1.High magnetic
2.Easy conjugation and separation
3.Highly uniform in size and shape
4.Excellent thermal, mechanical, and chemical stability
5.High surface area
Applications
1.Cell isolation, immunoassay, proteins and ligand immobilization
2.DNA/RNA purification
3.Drug delivery
4.Magnetic resonance imaging (MRI)
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