Mammalian cell expression has become the dominant recombinant protein production system for clinical applications because of its capacity for post-translational modification and human protein-like molecular structure assembly.

Mammalian cell-based expression systems have several advantages over other expression systems. According to Alpha Lifetech Inc, mammalian expression systems are the preferred system for the expression of mammalian proteins and can be used for the production of antibodies, complex proteins, and proteins for use in functional cell-based assays. Mammalian cells possess very effective protein secretion mechanisms that enable low-cost and high-purity protein purification. They also excel in terms of protein folding and post-translational modifications, often crucial for the activity and therapeutic effectiveness of recombinant proteins, as stated in. These systems offer incredibly high protein yields, and they have the capacity for post-translational modification and human protein-like molecular structure assembly, making them the dominant recombinant protein production system for clinical applications.