VHH antibodies (also known as nanobodies, single domain antibodies, or sdAbs) have been used in diagnostics, especially imaging, therapeutics (therapeutic antibodies, bispecific antibodies, CAR T, and ADCs), manufacturing, and research reagents. VHH antibodies differ from other conventional antibody formats in their unique size characteristics, intrinsic stability, solubility, easy tailoring into pluripotent constructs, recognition of rare or concealed epitopes, the ease and speed of drug discovery, and the ease of manufacture. Alpha Lifetech Inc. is recognized as a leader in single-domain antibody discovery. Alpha Lifetech Inc. has developed proprietary procedures for nanobody discovery.

The single domain nature of these antibodies provides unique advantages that set them apart for biotechnology applications. Some of these advantages include,

a) Stability at high temperatures & pH.

b) VHHs can recognize antigenic sites that are normally not recognized by conventional antibodies.

c) Their small molecular size helps with rapid tissue penetration and labeling applications, including crossing the blood-brain barrier.

d) Less expensive for large-scale production.