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Hydrophobe magnetic particles (HMPs) are a type of magnetic nanoparticle that can selectively bind to hydrophobic molecules, such as lipids or organic compounds. HMPs are widely used in various applications, including drug discovery, and biotechnology. The term "hydrophobe" refers to the fact that these particles are repelled by water and preferentially bind to hydrophobic molecules. This property makes them useful in applications where the target molecule is hydrophobic and difficult to separate from a complex mixture. HMPs are typically composed of a magnetic core, such as iron oxide, and a hydrophobic coating, such as a fatty acid or a surfactant. The magnetic core provides the particles with magnetic properties, while the hydrophobic coating allows them to selectively bind to hydrophobic molecules.

The size of HMPs can range from a few nanometers to several micrometers, depending on the specific application. Smaller particles are typically used for detection and separation, while larger particles are used for purification and isolation purposes. The magnetic properties of HMPs are critical for their use in separation and purification. The particles should have high magnetic susceptibility and low remanence to ensure efficient separation and minimal aggregation. The magnetic properties of HMPs can be controlled by adjusting the composition and synthesis conditions of the particles.



Fig.1 Hydrophobie


Biomedical Applications of Hydrophobe Magnetic Particles


The biomedical applications of hydrophobe magnetic nanoparticles include in vivo applications and in vitro applications. For in vitro applications, it is mainly used for diagnostic separation, selection, and magnetorelaxometry, while for in vivo applications, it could be further separated into therapeutic (hyperthermia and drug-targeting) and diagnostic (nuclear magnetic resonance [NMR] imaging).

1.In vivo applications

--Therapeutic applications: Hyperthermia. the transfer of magnetic energy to the particles in the form of heat, which can be used in vivo to increase the temperature of tumor tissues to destroy the pathological cells by hyperthermia.

--Drug delivery: The particles are functionalized with specific ligands that can bind to receptors on the surface of target cells. This allows for more precise and effective delivery of therapeutic agents while minimizing off-target effects.

--Diagnostic applications: NMR imaging. Giving patients magnetic drugs can enhance the image contrast between the normal and diseased tissue, and indicate the status of organ functions or blood flow.

2.In vitro applications

--Diagnostic applications: separation and selection, magnetorelaxometry, magnetic resonance imaging and bioseparation.

--Catalysis applications: catalysts supported by MNPs have been extensively used to improve the limitations of heterogeneous catalysis.


Production of Hydrophobe Magnetic Particles


The production of HMPs involves several steps, including the synthesis of the magnetic core, coating with a hydrophobic material, and functionalization with a ligand.

The synthesis of the magnetic core is typically achieved through a chemical reaction involving the precipitation of iron oxide or other magnetic materials. The size and shape of the particles can be controlled by adjusting the reaction conditions, such as the temperature, pH, and concentration of the reactants.

The hydrophobic coating is typically applied to the surface of the magnetic core through a variety of methods, such as chemical vapor deposition, sol-gel synthesis, or surface modification. The choice of coating material depends on the specific application and the desired properties of the particles.

Functionalization of the HMPs is achieved through the attachment of a ligand to the surface of the particles. The ligand can be a molecule that specifically binds to a target molecule, such as an antibody or aptamer, or a molecule that enhances the stability or dispersibility of the particles, such as a polymer.

The production of HMPs requires careful optimization of the synthesis conditions to ensure that the particles have the desired properties and performance.


Product Description


Hydrophobic magnetic particles are useful tool for the magnetic separation of biomolecules based on interactions of external hydrophobic regions of proteins, peptides, enzymes or nucleic acids. To increase the hydrophobicity of magnetic beads, Alpha Lifetech Inc. attach alkyl chains with different length are attached to the surface of beads, which including methyl (C1), ethyl (C2), propyl (C3), octyl (C8), Octadecyl(C18).


1.Functional group: methyl (C1), ethyl (C2), propyl (C3), octyl (C8), Octadecyl(C18).

2.Particle size: 1 μm

3.Type Magnetization: Superparamagnetic

4.Storage: Store at 4°C upon receipt. Do not freeze!

Quality advantage:

1.High magnetic

2.Easy conjugation and separation

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