Product Datasheet
|
Catalog Number |
ADT1018 |
|
Product Name |
Aflibercept Research Biosimilar |
|
Product Description |
Ablibercept is a recombinant fusion protein that acts as a decoy receptor for the ligands, vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PIGF). It prevents these ligands to binding to endothelial receptors, VEGFR-1 and VEGFR-2, to suppress neovascularization and decrease vascular permeability. |
|
CAS Number |
862111-32-8 |
|
Chemical Formula |
C4318H6788N1164O1304S32 |
|
Clonity |
Monoclonal |
|
Target |
VEGFA[Homo sapiens] |
|
Alias |
Aflibercept, Aflibercept (genetical recombination), Ziv-aflibercept, Aflibercept Research Biosimilar |
|
Host |
CHO Cells |
|
Isotype |
man IgG1 |
|
Size |
1mg,5mg |
|
Molecular Weight |
96.90 KDa |
|
Mechanism of Action |
Ablibercept is a recombinant fusion protein that acts as a decoy receptor for the ligands, vascular endothelial growth factor-A (VEGF-A) and placental growth factor (PIGF). It prevents these ligands to binding to endothelial receptors, VEGFR-1 and VEGFR-2, to suppress neovascularization and decrease vascular permeability. This ultimately will slow vision loss or the progression of metastatic colorectal cancer. |
|
Metabolism |
Because aflibercept is a protein, it is expected to be broken down via proteolysis into smaller peptides and amino acids. The cytochrome P450 enzyme system is not involved in the metabolism of aflibercept. |
|
Buffer |
Supplied in PBS, PH7.5 |
|
Concentration |
Batch dependent, please contact our customer service to get the COAs of current batch |
|
Purity |
>95% as determined by SDS-PAGE |
|
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
|
Shipping Condition |
This product is shipped in blue ice. |
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