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The controlled synthesis of asymmetric nanoparticles, called anisotropy, is a very attractive research topic in the scientific community. Anisotropic nanoparticles mainly include nanorods, nanourchins and nanocages. Gold nanospheres (AuNUs), also known as gold nanospheres or gold nanostars, are multi-branched nanoparticles. The surface of gold nanourchins is a unique peak with a tunable surface plasmon resonance (SPR) peak , which can be adjusted to emit in the near-infrared spectral regions.

Up to now, the SPR peak of most gold nanourchins (AuNUs) studied is between 550 and 800 nanometers. This is critical for in vivo use because tissue absorbs less and penetrates deeper in near-infrared environments. In addition, at the tip of AuNUs spikes, the electromagnetic field increased significantly. The resulting surface-enhanced Raman scattering (SERS) has been used for AuNU-mediated Raman imaging with excellent sensitivity.


Applications of Gold NanoUrchins


NanoUrchins (GNUs) have shown great potential in biomedicine due to their unique shape and size.

--Drug deliver: GNUs can be functionalized with various biomolecules, allowing for targeted delivery of drugs and imaging agents to specific cells and tissues.

--photodynamic therapy (PDT): GNUs can also be used in photothermal therapy, where they absorb light and convert it into heat, killing cancer cells. 

According to a study published in the Journal of Controlled Release, GNUs functionalized with anti-HER2 antibodies were able to selectively target HER2-positive breast cancer cells in vitro and in vivo. 

In addition, nanoUrchins (AuNUs) may play a great role in maintaining human health, and can be applied to biosensing,  catalysis, immunotherapy, in vivo imaging and photothermal therapy (PTT) .


Production of Gold NanoUrchins:


The most difficult thing to grasp in the preparation of gold nanoUrchins is to ensure the stability and repeatability of the products. In general, AUNUs can be obtained through two different methods: the growth of seed interventions caused by the presence of capping agents and the one-pot aggregation of many seeds

The initial method of synthesis was based on the reduction of HAuCl4 using sodium hydroxide, CTAB, ascorbic acid (AA) as a reducing agent, and silver nanoplates as a catalyst. Numerous reducing agents have been used in the one-pot synthesis, including ascorbic acid, sodium citrate, H2O2, and N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid (HEPES). Using these techniques, it is difficult to control the uniformity of multi-branch nanoparticles, and the final nanoparticles often show initial aggregation, followed by the formation of several seeds.  These morphologies are frequently referred to as "sea urchin," "nanoflower," or "raspberry."


Product Description:


Our company has launched gold nanoparticles products for life science and materials science applications. The gold nanoUrchins Alpha Lifetech Inc. provide have diameters ranging from 50 nm to 100 nm, and have different surface functionalizations and are soluble in different solvents. The Pack Size is 1EA.

Compared with other gold nanoparticles, our products have the following advantages:

1. Narrow size range distribution -- Based on the conclusion of dynamic light scattering (DLS) and TEM analysis. Each batch of products will be tested by DLS and UV- visible spectrum analysis.

2. Consistent size and shape -- coefficient of variation (CV) is less than 10%.

Compared with spherical gold nanoparticles with the same inner diameter, gold nanoUrchins has its special optical properties. The sharp and uneven surface makes the peak of surface plasmon resonance redshift. Compared with spherical particles, the electromagnetic field at the tip of gold nanoUrchins surface is greatly enhanced.