Product Datasheet
|
Catalog Number |
ALP64521 |
|
Product Name |
Recombinant Human CD172a Protein, His Tag, Avi Tag |
|
Description |
ALP64521 Recombinant Human CD172a Protein, His Tag, Avi Tag is produced in HEK293 Cells and the target gene encoding Glu31-Arg370 is expressed with a 6His, Avi tag at the C-terminus. |
|
Official Symbol |
CD172a |
|
Protein Family |
|
|
Expression Host |
HEK293 Cells |
|
Alias |
CD172a, SHPS-1 |
|
Species |
Human |
|
Size |
50ug, 100ug |
|
Purification |
Affinity Purification |
|
Endotoxin |
<1.0 EU/ug determined by the LAL method |
|
Purity |
>90%-95% as determined by SDS-PAGE |
|
Buffer |
20mM PB, 150mM NaCl, pH7.2 |
|
Uniprot |
|
|
Background |
Signal Regulatory Protein α(SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation |
|
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
|
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
|
Note |
This product is for research use only. This product can not be used for human. |
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