Product Datasheet
|
Catalog Number |
ALP64518 |
|
Product Name |
Recombinant Human Tie-2 Protein, Fc Tag |
|
Description |
ALP64518 Recombinant Human Tie-2 Protein, Fc Tag is produced in HEK293 Cells and the target gene encoding Ala23-Leu748 is expressed with a Fc tag at the C-terminus. |
|
Official Symbol |
Tie-2 |
|
Protein Family |
Tie Subfamily |
|
Expression Host |
HEK293 Cells |
|
Alias |
angiopoietin-1 receptor, CD202b |
|
Species |
Human |
|
Size |
50ug, 100ug |
|
Purification |
Affinity Purification |
|
Endotoxin |
<1.0 EU/ug determined by the LAL method |
|
Purity |
>90%-95% as determined by SDS-PAGE |
|
Buffer |
Supplied in PBS, pH7.4 |
|
Uniprot |
|
|
Background |
Tie-1/Tie(tyrosine kinase with Ig and EGF homology domains 1) and Tie-2/Tek comprise a receptor tyrosine kinase(RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor(EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human Tie-2 cDNA encodes a 1124 amino acid(aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Two ligands, angiopoietin-1(Ang-1) and angiopoietin-2(Ang-2), which bind Tie-2 with high-affinity have been identified. Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects. |
|
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
|
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
|
Note |
This product is for research use only. This product can not be used for human. |
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