Product Datasheet
|
Catalog Number |
ALP64509 |
|
Product Name |
Recombinant Human Siglec-10 Protein, mFc Tag |
|
Description |
ALP64509 Recombinant Human Siglec-10 Protein, mFc Tag is produced in HEK293 Cells and the target gene encoding Met17-Thr546 is expressed with a mFc tag at the C-terminus. |
|
Official Symbol |
Siglec-10 |
|
Protein Family |
Siglec Family |
|
Expression Host |
HEK293 Cells |
|
Alias |
Siglec10, MGC126774 |
|
Species |
Human |
|
Size |
50ug, 100ug |
|
Purification |
Affinity Purification |
|
Endotoxin |
<1.0 EU/ug determined by the LAL method |
|
Purity |
>90% as determined by SDS-PAGE |
|
Buffer |
Supplied in PBS, pH7.4 |
|
Background |
Siglecs(sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. Siglec-G is the apparent ortholog of human Siglec-10. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell. When tyrosine phosphorylated, the cytoplasmic ITIMs interact with phosphatases SHP-1 and SHP-2 to propagate inhibitory signals. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products. |
|
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
|
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
|
Note |
This product is for research use only. This product can not be used for human. |
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