Product Datasheet
|
Catalog Number |
ALP64520 |
|
Product Name |
Recombinant Human CD40L Protein, mFc Tag |
|
Description |
ALP64520 Recombinant Human CD40L Protein, mFc Tag is produced in HEK293 Cells and the target gene encoding Met113-Leu261 is expressed with a mFc tag at the N-terminus. |
|
Official Symbol |
CD40L |
|
Protein Family |
|
|
Expression Host |
HEK293 Cells |
|
Alias |
Tumor Necrosis Factor Ligand Superfamily Member 5, CD154 |
|
Species |
Human |
|
Size |
50ug, 100ug |
|
Purification |
Affinity Purification |
|
Endotoxin |
<1.0 EU/ug determined by the LAL method |
|
Purity |
>90% as determined by SDS-PAGE |
|
Buffer |
Supplied in PBS, pH7.4 |
|
Uniprot |
|
|
Background |
CD40 Ligand(CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2. |
|
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
|
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
|
Note |
This product is for research use only. This product can not be used for human. |
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