Product Datasheet
|
Catalog Number |
ALP64522 |
|
Product Name |
Recombinant Human BTLA/CD272 Protein, mFc Tag |
|
Description |
ALP64522 Recombinant Human CD272 Protein, mFc Tag is produced in HEK293 Cells and the target gene encoding Lys31-Leu150 is expressed with a mFc tag at the C-terminus. |
|
Official Symbol |
BTLA |
|
Protein Family |
|
|
Expression Host |
HEK293 Cells |
|
Alias |
B- and T-Lymphocyte Attenuator, CD272 |
|
Species |
Human |
|
Size |
50ug, 100ug |
|
Purification |
Affinity Purification |
|
Endotoxin |
<1.0 EU/ug determined by the LAL method |
|
Purity |
>90%-95% as determined by SDS-PAGE |
|
Buffer |
Supplied in PBS, pH7.4 |
|
Uniprot |
|
|
Background |
B- and T-Lymphocyte Attenuator(BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type(immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors(TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor(receptor) superfamily, member 14(TNFRSF14), also known as herpes virus entry mediator(HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses. |
|
Storage |
For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles. |
|
Shipping Condition |
Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice. |
|
Note |
This product is for research use only. This product can not be used for human. |
.jpg){kind=logo}
